Mo1691 Enhanced Indomethacin-Induced Gut Injury in Formula-Fed Rat Pups
نویسندگان
چکیده
منابع مشابه
Gut Microbial Gene Expression in Mother-Fed and Formula-Fed Piglets
BACKGROUND Effects of diet on the structure and function of gut microbial communities in newborn infants are poorly understood. High-resolution molecular studies are needed to definitively ascertain whether gut microbial communities are distinct in milk-fed and formula-fed infants. METHODOLOGY/PRINCIPAL FINDINGS Pyrosequencing-based whole transcriptome shotgun sequencing (RNA-seq) was used to...
متن کاملComparison of the gut microbiota profile in breast-fed and formula-fed Korean infants using pyrosequencing
BACKGROUND/OBJECTIVES Feeding in infancy is the most significant determinant of the intestinal microbiota in early life. The aim of this study was to determine the gut microbiota of Korean infants and compare the microbiota obtained between breast-fed and formula-fed Korean infants. SUBJECTS/METHODS We analyzed the microbial communities in fecal samples collected from twenty 4-week old Korean...
متن کاملGut Microbiota Mediates Protection Against Enteropathy Induced by Indomethacin
Non-steroidal anti-inflammatory drugs (NSAIDs) can cause significant small bowel injuries. The role of gut microbiota in this NSAID-induced enteropathy is poorly understood. We studied the dynamic changes in gut microbiota following indomethacin administration in mice, and investigated the effects of these adaptive changes on subsequent NSAID-induced enteropathy. The changes in gut microbiota w...
متن کاملPartial suppressive effect of melatonin on indomethacin-induced renal injury in rat.
Intramuscular injection of a single high dose of indomethacin (20 mg/kg) in fasted rats produced renal injury. The results showed increases in the level of lipid peroxidation and cholesterol, and activity of acid phosphatase and alkaline phosphatase in the kidney. Also, the renal contents of both reduced glutathione and activity of total adenosine triphosphatase were decreased by the toxicant. ...
متن کاملGastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.
BACKGROUND In contrast with earlier reports that neutrophils play a primary part in non-steroidal anti-inflammatory drug (NSAID) injury to the stomach, recent evidence suggests only a secondary role for these cells. AIM To examine whether early microscopic changes induced by indomethacin in the gastric corpus of fasted rats and the antrum of fasted-refed rats involve neutrophil infiltration. ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2014
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(14)62308-8